Syngenta Group announced new collaborations following the launch of its innovation accelerator platform Shoots by Syngenta in 2023. These collaborations, which connect expertise across industries and sectors, aim to make novel solutions to agricultural challenges possible more quickly and efficiently.
Two collaborations — with IBM Research and biotech Maxygen — brought their respective pioneering approaches in data-based prediction modeling and the directed evolution of proteins more commonly leveraged in the pharmaceutical industry, together with Syngenta’s world-leading agricultural research and proprietary data sets.
“Helping growers sustainably feed a rapidly growing human population requires a strong collaboration focus, not just across agriculture but across industries,” said Gusui Wu, Global Head of Seeds Research. “Collaboration is at the heart of how our scientists approach innovation every day. It is embedded in our scientific culture, and we are continually seeking out different technologies, solutions, and partners to help us better serve farmers.”
IBM Research and Syngenta accelerate the optimization of chemical compound synthesis with language models
Syngenta Group, in collaboration with IBM Research, has enhanced productivity in chemical synthesis using IBM-RXN — a software developed to enable language models to synthesize new molecules and materials. IBM-RXN encodes, models, and predicts chemical reactivity. Combining Syngenta’s world-leading chemistry research and proprietary data sets with IBM’s world-class reactivity modeling capabilities and leveraging Natural Language Processing, IBM’s pioneering modeling approach enables the partners to deliver scalable, accurate, and data-based prediction modeling. This enables Syngenta to investigate multiple related compounds simultaneously and prioritize routes that offer compounds with the most desirable commercial attributes.
Syngenta closes the data loop by connecting the IBM-RXN platform to the synthesis platform. Reactivity predictions are now an integral part of the design of synthetic procedures. The models’ outcomes are fully integrated with synthesis planning and execution, establishing a virtual loop where high-quality data generate more relevant models that, in turn, inspire better synthetic procedures. The digitalization of synthetic workflows and the adoption of predictive reactivity modeling are increasing the efficiency and effectiveness of the synthetic process. Both teams worked on extending reactivity modeling to include bio-catalyzed reactions and metabolic transformations to support the design of more sustainable synthetic procedures with better safety and environmental footprint.
As the predictive power of reactivity models increases, scientists may become increasingly confident in delegating part of their work to AI-enabled automation. This should allow shifting the focus to the synthesis strategy and overall chemical design.
Syngenta collaborates with Maxygen to optimize molecular enabling technology
U.S. biotech Maxygen, specializing in the directed evolution of proteins, is collaborating with Syngenta Seeds to optimize its enabling technologies.
Since the collaboration launched, one of the success factors has been the consistent and robust scientific engagement on both sides. Maxygen and Syngenta adopted an open collegiate approach from the start, with Syngenta giving the collaboration a high-priority status as part of its core portfolio, enabling the project to progress swiftly.
The teams from Syngenta and Maxygen met frequently to review results, manage decision-making, adjust plans, and mark progress milestones. This approach has delivered success, resulting in protein variants with highly improved attributes and the subject of novel intellectual property.
Seeking new collaborators for six challenges
Shoots by Syngenta spotlights specific innovation needs across the Syngenta Crop Protection and Seeds businesses. Science-based innovation challenges are posted on its website, inviting anyone with a scientific interest to submit proposals in response. Proposals are quickly evaluated, and if there is a mutual fit, progress to a collaboration partnership to take forward the research or technology that might eventually be licensed.
Shoots by Syngenta lists six challenges, ranging from identifying new chemical building blocks derived from biomass waste streams to developing diagnostic tools for detecting non-visible indicators of poor crop growth.
“We’re looking forward to connecting with new partners from academia, research institutes, start-ups, and cross-industry sectors to work with our extensive global network of scientists and to push the boundaries of what is known today in science,” said Camilla Corsi, Syngenta’s Global Head of Crop Protection Research. “We’re proud of our strong reputation as a collaborator of choice and are excited about the potential of the Shoots by Syngenta platform to generate new possibilities to benefit farmers and agriculture.”